Which statement is false about skeletal muscle histology?

Which statement is false about skeletal muscle histology?

• A. Endomysium surrounds each muscle fiber
• B. Perimysium surrounds a fascicle
• C. Epimysium surrounds the entire muscle
• D. Myelin sheath surrounds skeletal muscle fibers

Answer: (D)

In skeletal muscle histology, the tissue is organized by connective tissue layers: endomysium surrounds each individual muscle fiber, perimysium wraps a fascicle of fibers, and epimysium encloses the entire muscle. The statement about a myelin sheath surrounding skeletal muscle fibers is not correct because the myelin sheath is the insulating layer around nerve fibers (axons), produced by Schwann cells in the peripheral nervous system. Muscle fibers have a membrane called the sarcolemma, not a myelin sheath, and they receive their signal to contract via innervation from motor neurons whose myelinated axons reach the neuromuscular junction. So, the other statements accurately describe the connective tissue organization, while the claim about a myelin sheath around muscle fibers is false.

In skeletal muscle histology, the tissue is organized by connective tissue layers: endomysium surrounds each individual muscle fiber, perimysium wraps a fascicle of fibers, and epimysium encloses the entire muscle. The statement about a myelin sheath surrounding skeletal muscle fibers is not correct because the myelin sheath is the insulating layer around nerve fibers (axons), produced by Schwann cells in the peripheral nervous system. Muscle fibers have a membrane called the sarcolemma, not a myelin sheath, and they receive their signal to contract via innervation from motor neurons whose myelinated axons reach the neuromuscular junction. So, the other statements accurately describe the connective tissue organization, while the claim about a myelin sheath around muscle fibers is false.